Monday, January 11, 2010

Bacteria walks with the hep of CALCIUM

Pseudomonas aeruginosa is an opportunitistic human pathogen. It is a common cause of hospital-acquired Pneumonia.
It walks with the help of pili. A protein called PilY1 is necessary for the formation of these pili.
Scientist have resolved the crystal structure of this protein and found a binding site for single Calcium atom in it.
When this site was blocked so that no calcium could bind, bacteria could not move further.

This discovery can help in drug development against this pathogen or may be others also.

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